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The characterization of molecules is an important part of the process, enabling the physical and chemical properties of molecules to be resolved. CD BioSciences has excellent analytical staff, years of analytical experience, and cutting-edge instrumentation. Using LC-MS, multiple HPLC, and other techniques, we can accurately quantify/characterize the DAR of coupled drugs, residual small molecules, endotoxins, and more.
Specifications
1. Electron source: High-brightness field emission gun (X-FEG)
2. Accelerating voltage: 200 kV
3. Cs: 2.7 mm
4. Cryo-Autoloader: Automated loading of grids from cassettes, containing up to 12 Autogrids
5. Software Ceta CCD camera: EPU Software for SPA sample assessment, optimization
6. Software Gatan K3: SerialEM optimized for automated acquisition of images/movies
7. Lenses: Symmetric constant power objective lens (minimizes image aberrations and lens hysteresis during mode switching)
8. Stage: Computerized 4-axes specimen stage with ±70° alpha tilt (Compustage)
9. Imaging: Rotation-free imaging upon magnification changes
10. Pole piece gap: 11 mm
1. The Glacios is an advanced cryo-transmission electron microscope that can used in a single particle analysis (SPA) workflow for pre-screening and assessment of sample quality before transferring to the Titan Krios cryo-TEM for ultimate-resolution SPA data acquisition.
2. EPU software can be used for automated atlas screening to gauge grid ice quality using the Ceta camera. Furthermore, the Glacios cryo-TEM is configured with a K3 Direct Electron Detector to be a complete standalone SPA data acquisition solution. Digital FluCam can be used for initial alignments, microscope set-up and optimization.
3. SerialEM software is used for longer term unattended acquisition after suitable grid selection and set-up. Electron tomography applications are also possible under SerialEM.
Configuration
1. 200kV X-FEG optics. C-TWIN objective lens. Autoloader for multi-grid loading at cryo-LN2 temperature and automated exchange of grid to column.
2. The Glacios instrument is housed in a metal system enclosure which reduces its sensitivity to sound and temperature disturbances or fluctuations.
3. Two detectors are present; Thermo Fisher Scientific CETA 16M Pixel CMOS camera ideal for screening and setting up sessions; Gatan K3 2416M Pixel (5,760 × 4,092) direct Electron Detector .
4. Fitted with a Volta Phase Plate.
5. EPU and SerialEM software for automated EM data acquisition.
CD BioSciences offers its customers Thermo Fisher Scientific Glacios TEM-based molecular characterization services that contribute to the process and drug development process of biomolecules. If you need our technical support, please contact us directly.
Please fill out the form below and we will get back to you as soon as possible with a quotation for the item you are interested in.
CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.