Molecular Characterization Service—Differential Scanning Calorimeter

The characterization of molecules is an important part of the process, enabling the physical and chemical properties of molecules to be resolved. CD BioSciences has excellent analytical staff, years of analytical experience, and cutting-edge instrumentation. Using LC-MS, multiple HPLC, and other techniques, we can accurately quantify/characterize the DAR of coupled drugs, residual small molecules, endotoxins, and more.

Name of the Instrument/Platform

Differential Scanning Calorimeter

Feature Highlights

1. Active cell volume ~ 0.5 mL.
2. Non-reactive Tantalum 61^™ cells for excellent chemical resistance.
3. Fixed-in-place cells for reproducible µLtrasensitive performance with low maintenance.
4. Operating temperature range of -10℃ to +130℃.
5. Peltier element for precise temperature control.
6. User selectable temperature scan rates (0℃ to 90℃ per hour upscans) and range for application versatility.

Applications

1. Protein stability and folding.
2. Protein engineering.
3. Characterization of membranes, lipids, nucleic acids and micellar systems.
4. Assessment of the effects of structural change and ligand binding on a molecule's stability.

Summary

The MicroCal (GE Healthcare) differential scanning calorimeter directly measures the enthalpy of a solution as a function of temperature.

CD BioSciences offers its customers Differential Scanning Calorimeter-based molecular characterization services that contribute to the process and drug development process of biomolecules. If you need our technical support, please contact us directly.

For research use only, not intended for any clinical use.

Related Services