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The characterization of molecules is an important part of the process, enabling the physical and chemical properties of molecules to be resolved. CD BioSciences has excellent analytical staff, years of analytical experience, and cutting-edge instrumentation. Using LC-MS, multiple HPLC, and other techniques, we can accurately quantify/characterize the DAR of coupled drugs, residual small molecules, endotoxins, and more.
The system works in tandem with an Optilab refractometer with extended range (T-rEX), to determine the absolute concentrations of analytes. When coupled with gel-filtration chromatography, this MALS/T-rEX combination system can easily detect the molecular weight, spatial size, and concentration of macromolecules in mixed solutions. This allows users to identify, characterize, and determine relative abundance of complexes formed by mixed analytes, or the oligomerization states of single proteins. As currently operated, our system is suited to aqueous systems and relatively large molecules only.
The Wyatt miniDawn TREOS is a multi-angle light scattering detector (MALS), reading at three different angles. This instrument is capable of calculating molecular weights and average dimensions of macromolecules and complexes in solution with great accuracy.
CD BioSciences offers its customers Wyatt miniDawn TREOS-based molecular characterization services that contribute to the process and drug development process of biomolecules. If you need our technical support, please contact us directly.
Please fill out the form below and we will get back to you as soon as possible with a quotation for the item you are interested in.
CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.