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CD BioSciences fermentation services are tailored to the needs of our customers. We have the high density fermentation technology and process optimization to provide you with transformed bacterial cytoplasm (bacteriophage), as well as gram-level homologous recombinant proteins with up to 98% purity. Customers can choose the right fermentation solution for their needs.
The conditions of cell disruption can be carefully controlled by adjusting the applied pressure. It is most useful for small volumes of cell suspension (less than 35 mL) or when the cells of microorganisms need to be broken in a very controlled way; for example, it can be used to prepare inside-out sub-bacterial vesicles from intact cells.
The Microbiology Core Facility has two "cells" for this device: A standard-volume cell that holds approximately 35 mL, and and a"mini" cell that holds approximately 7 mL.
Since the French Pressure Cell does not always shear the DNA released when cells break, it is recommended to add DNAase (and Mg2+) prior to processing to avoid high viscosity conditions
The "French Pressure Cell" disrupts ("breaks") the cells of microorganisms by elevating the cell suspension to a high pressure and then allowing it to escape back to ambient pressure through a small orifice. An alternative to the French Pressure Cell is the Microfluidizer, which operates on a similar principle but is suitable for much larger volumes.
CD BioSciences' French Pressure Cell Disruptor-based fermentation services can be applied to protein purification. If you need technical support in this area, please feel free to contact us.
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CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.