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Cryo-electron microscopy (CryoEM) applies cryo-fixation technology to observe samples with a transmission electron microscope at low temperatures, to obtain the microscopic technology of the structure of biological macromolecules. After the piece is frozen and placed in the electron microscope, the electrons are scattered through the sample and the nearby ice layer. Use the detector and lens system to image and record the scattered signal, then process the signal, and finally use the three-dimensional reconstruction technology to obtain the three-dimensional structure of the sample. CryoEM imaging services are provided by CD BioSciences based on Thermo Fisher-FEI Talos Arctica.
Performance Metrics
In order to validate performance, our instruments are routinely tested to ensure high-resolution instrument performance. The FEI Talos Arctica's performance has been validated to 2.5 Angstrom resolution using Aldolase as a well studied target structure.
The FEI Talos Arctica is a 200keV high- performance automated transmission electron microscope designed specifically for cryo-electron microscopy. This system is capable of reaching 2.5 Angstrom resolution. The Falcon 3 direct detection device's counting mode and drift correction produce high signal-to-noise and high-resolution images for tomography and single-particle data. The system is equipped with a Volta phase plate that makes imaging of very small (less than 200kDa) proteins possible. The Arctica is primarily used for medium resolution structures that can then be passed to the Krios for very high-resolution imaging and reconstruction.
CD BioSciences offers its customers the CryoEM imaging service based on Thermo Fisher-FEI Talos Arctica to help analyze the 3D structure and microstructure of samples. If you are interested, please feel free to contact us.
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CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.