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CryoEM is a microscopy technique that applies a freeze-fixation technique to obtain the structure of biological macromolecules by using transmission electron microscopy to view samples at low temperatures. The sample is cryo-fixed and placed in an electron microscope where electrons are scattered in the sample and nearby ice. CD BioSciences uses a detector and lens system to image and record the scattered signals, which are then processed using 3D reconstruction techniques to obtain the 3D structure of the sample.
Life Science configuration for single particle data collection and dual axis cellular tomography:
1. Cs: spherical aberration corrector
2. Volta Phase Plate for enhanced contrast
3. Falcon 4 direct electron detector camera
4. Quantum GIF (K2) energy filter with K2 direct electron detector
Material Science configurations:
1. Analytical
2. EELs for elemental mapping and chemical bonding
3. Imaging
4. STEM for mass/thickness contrast
5. DPC: differential phase contrast produces contrast relative to electrical fields
6. EFTEM: energy filtered TEM for zero loss imaging of thick samples
Configured for uncompromised data collection for the life sciences the Krios also incorporates material science applications, making the system uniquely suited to use material science applications on biological samples. This combination opens up a new era of convergence science blending technical approaches to develop cutting edge approaches to understand both soft and hard materials.
The FEI Titan Krios is an instrument that realizes the revolutionary developments in cryo-EM leading to the "resolution revolution" that allows atomic resolution maps of biological objects with low or no symmetry. These transformative advances include the exceptionally stable microscope stage, automated data collection, direct electron detection technology, fast read out for data transfer.
CD BioSciences offers its customers the CryoEM imaging service based on FEI Titan Krios to help analyze the 3D structure and microstructure of samples. If you are interested, please feel free to contact us.
Please fill out the form below and we will get back to you as soon as possible with a quotation for the item you are interested in.
CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.