The characterization of molecules is an important part of the process, enabling the physical and chemical properties of molecules to be resolved. CD BioSciences has excellent analytical staff, years of analytical experience, and cutting-edge instrumentation. Using LC-MS, multiple HPLC, and other techniques, we can accurately quantify/characterize the DAR of coupled drugs, residual small molecules, endotoxins, and more.
LC-SPE-NMR-MS (a hyphenated LC-NMR spectroscopy system with enhanced sample recovery combined with real-time MS analysis and high-through-put capabilities). The system consists of an Agilent 1260 HPLC with DAD detection coupled to a Bruker NMR-MS-Bridge (splitter), a Bruker micrOTOF mass spectrometer (shared resource), a Bruker ProspekII SPE (solid phase extraction) unit and a Gilson 215 liquid handler. The system allows for NMR analysis of known and unknowns following reversed-phased or HILIC chromatography. Analytes can be trapped as fractions or on solid-phase-support (SPE) cartridges for drying, elution with deuterated NMR solvents and NMR analysis with real-time collected MS analysis.
CD BioSciences offers its customers LC-SPE-NMR-MS-based molecular characterization services that contribute to the process and drug development process of biomolecules. If you need our technical support, please contact us directly.
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CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.