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Molecular Characterization Service—FEI Talos F200C TEM

The characterization of molecules is an important part of the process, enabling the physical and chemical properties of molecules to be resolved. CD BioSciences has excellent analytical staff, years of analytical experience, and cutting-edge instrumentation. Using LC-MS, multiple HPLC, and other techniques, we can accurately quantify/characterize the DAR of coupled drugs, residual small molecules, endotoxins, and more.

Name of the Instrument/Platform

FEI Talos F200C TEM

MANUFACTURER:
FEI

Introduction

Talos F200C Specifications
1. Electron source: Field Emission Gun, operated at 200kV
2. TEM information limit (nm): 0.18
3. TEM point resolution (nm): 0.30
4. Cs: 2.7 mm
5. TEM magnification range: 25×–640kx
6. Camera Detector:
Thermo Fisher Scientific Ceta 16M CCD
1) 4096 × 4096, 14 µm pixel
2) 16 bit dynamic range
3) Conversion efficiency, 9 counts/primary electron (typical) at 200kV

Applications

The FEI Talos transmission electron microscope (TEM) is a powerful, versatile electron microscope system for delivering high-resolution characterization of biological and biomaterials samples in cell biology, structural biology, and nanotechnology research. The Talos enables researchers to quickly obtain a better insight and understanding of macromolecular structures, cellular components, cells and tissues.
The system's constant-power, C-Twin lens delivers outstanding optical performance to help ensure an optimal balance of contrast and resolution. The FEI/ Thermo Fisher Scientific Talos platform includes a tiltable stage (Compustage) for stable imaging of side-entry holders at room temperature and also under cryo-conditions.

Summary

Configuration
1. 200kV FEG Optics. Cryo-capable with insertable/retactable cryo box. Gatan 626 side-entry cryo holders (LN2 temperature). FEI Ceta 16M Pixel CMOS camera. STEM function.
2. The Talos instrument is housed in a metal enclosure which reduces its sensitivity to environmental disturbances.
3. TIA and VELOX are used for imaging and SerialEM is also installed for automated acquisition and tomography applications.

CD BioSciences offers its customers FEI Talos F200C TEM-based molecular characterization services that contribute to the process and drug development process of biomolecules. If you need our technical support, please contact us directly.

For research use only, not intended for any clinical use.
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