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The characterization of molecules is an important part of the process, enabling the physical and chemical properties of molecules to be resolved. CD BioSciences has excellent analytical staff, years of analytical experience, and cutting-edge instrumentation. Using LC-MS, multiple HPLC, and other techniques, we can accurately quantify/characterize the DAR of coupled drugs, residual small molecules, endotoxins, and more.
Circular dichroism (CD) is the difference in the absorbance of left-handed circularly polarised light (L-CPL) and right-handed circularly polarised light (R-CPL) and occurs when a molecule contains one or more chiral chromophores (light-absorbing groups). A primary use is in analysing the secondary structure or conformation of macromolecules, particularly proteins, and because secondary structure is sensitive to its environment, e.g. temperature or pH, circular dichroism can be used to observe how secondary structure changes with environmental conditions or on interaction with other molecules.
1. Analysis of secondary structure or conformation of macromolecules or supramolecular aggregates in solution.
2. measuring changes in secondary structure due to binding events between molecules.
3. measuring changes in secondary structure due to temperature changes (eg. oligonucleotide melting) or chemical denaturation.
Cuvette holder options: 1 cm, 1 mm, 0.5 mm, 0.2 mm and 0.1 mm.
Variable temperature accessory for 1 cuvette or 4 cuvettes.
Circular Dichroism: Applied Photophysics Chirascan Plus CD spectrometer for analysing secondary structure or conformation of macromolecules or gels.
CD BioSciences offers its customers Applied Photophysics Chirascan Plus CD-based molecular characterization services that contribute to the process and drug development process of biomolecules. If you need our technical support, please contact us directly.
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CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.