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Confocal microscopy is an optical imaging technique that uses point-by-point illumination and spatial pinhole modulation to remove scattered light from the non-focal plane of the sample, allowing for improved optical resolution and visual contrast compared to traditional imaging methods. CD BioSciences, the imaging experts, can provide you with Olympus IX81 TIRF Microscope-based confocal microscopy imaging services.
The result is superior signal-to-noise since structures outside the focal plane are never illuminated. TIRF microscopy is also suitable for studying membrane dynamics in living cells since the laser does not induce damage.
Olympus IX81 in lab at Rensselaer
Olympus IX81 TIRF Microscope
The TIRF system consists of an Olympus IX81 with ZDC stage control fitted with 3 lasers (488, 543 and 633 nm) to accommodate a wide range of experimental demands. Phase contrast, DIC and widefield fluorescence modalities are also available. The Asylum MFP-3D atomic force microscope can also be mounted on the microscope to obtain force and conductivity measurements as well as structural information on the nanometer scale.
Total internal reflection fluorescence (TIRF) microscopy is ideal for visualizing structures in the immediate vicinity (~100 nm) of the coverslip including cell membrane structure and dynamics, and for resolving single molecules (e.g. DNA, cytoskeletal motility assays).
The system operates by bouncing a laser beam off of the coverslip so that photons never hits the specimen directly; however the radiating evanescent wave is sufficient to illuminate fluorescent structures nearby.
CD BioSciences' Olympus IX81 TIRF Microscope-based confocal microscopy service is an ideal partner for cutting-edge biomedical research, providing precise 3D imaging, as well as accurate imaging of cell structure and dynamic processes, all in one package. If you are interested, please feel free to contact us.
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CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.