Imaging and Analysis Services—ImageXpress Micro Confocal High-Content Imaging System

CD BioSciences offers a unique range of high-end custom fluorescence microscopes, small animal imaging devices, and fluorescent probes to perform fluorescence-based measurements in a variety of spatial (nm to cm), and temporal (ns). Our laboratories offer consultancy services and support the application of novel spectroscopic methods and advanced microscopy techniques to achieve high spatial and temporal resolution nanotechnology from whole in vivo animal imaging to sub 70 nm imaging using super-resolution. In addition to using state-of-the-art specialist instrumentation, we train researchers in the use of advanced imaging techniques that are used to study macromolecules, and cell dynamics and characterize biological materials with nanometric precision.

Name of the Instrument/Platform

ImageXpress Micro Confocal High-Content Imaging System

Introduction

The key feature of the device is on board robotic fluidic head, including the following specifications: automated liquid handling for compound/media addition; ability to perform well washing using disposable pipette tips; add, wash, and dispense into user configurable patterns; fully customized workflow through scripting; single-channel pipettor with dispense volumes from 3 µL to 200 µL (±1 µL ±5%); supports 96- or 384-well format pipette tips; holds two temperature-controlled plates for compound addition or media exchange; 3D analysis tools are integrated into acquisition and analysis software and are able to measure volumes, diameters, and distances in 3 dimensions. In addition, software runs on 8 parallel processors for fast, multi-threaded analysis.

Technical Capabilities

1. Select a confocal geometry optimal for your assay and throughput needs
2. Achieve excellent image quality without sacrificing throughput via our unique optical path technology
3. Acquire statistically relevant data quickly with an advanced scientific CMOS detector, enabling > 3 log dynamic range
4. Large field of view enables whole-well imaging
5. Expand your research capabilities with transmitted light, liquid handling, and environmental options

Important Notes

Confocal technology at the speed of widefield imaging:
1. Capture an entire well of a 384‑well plate with a single image at 4× magnification
2. Capture four wells of a 1536- well plate in a single image at 4× magnification
3. Throughput of > 160K wells/day confocal, > 200K wells/day widefield 2 ImageXpress

Summary

This versatile imaging system features a unique confocal technology, which allows you to explore more physiologically, relevant, complex three dimensional models, including spheroids, tissues, and whole organisms and to generate publication quality images at high throughput for samples in slides or one to 1536‑well microplates.

CD BioSciences offers ImageXpress Micro Confocal High-Content Imaging System-based imaging and analysis services to researchers from all over the world. Our solutions will fully meet your experimental needs. We sincerely look forward to establishing a partnership with you. If you have any questions, please contact us directly.

For research use only, not intended for any clinical use.

Related Services