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Rely on CD BioSciences' experienced genomics services to deliver high-quality, interpretable results using highly sensitive PCR, real-time PCR, NGS technologies, and advanced data analysis. All of your genomics research needs can be met with our highly flexible and customizable platform and our long experience in analyzing preclinical research samples.
The GeoMxTM detects target proteins or RNA species using antibodies or hybridization probes, respectively, that are conjugated to indexing oligos. These oligos are conjugated by a UV-cleavable linker, and they are released from the slide by highly localized digital UV illumination. This step imparts spatial information for each sample. The released oligos are collected from an aqueous layer above the tissue slice over each region of interest (ROI) by automated capillary pipette and then transferred into microwells for index counting. This last step can utilize either Nanostring nCounter technology or NGS, which allows a nearly limitless degree of multiplexing. Note that the original tissue is not destroyed, because the UV-cleaved index oligos are recovered while the original proteins and RNAs remain in place.
Non-destructive, highly multiplexed, multi-omics technology that quantifies target proteins and transcripts in spatially defined areas of a microscopy slide. Thus, it allows cell type-specific analysis of frozen, paraffin embedded and FFPE tissues.
CD BioSciences offers you Nanostring GeoMx Digital Spatial Profiler-based genomic services. If you are interested, please feel free to contact us for more information.
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CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.