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CD BioSciences' chemical and biomolecular analysis laboratories have a wide range of instruments including high-field nuclear magnetic resonance (NMR), liquid chromatography-mass spectrometry (LC-MS), gas chromatography-mass spectrometry (GC-MS), high-performance liquid chromatography (HPLC) and more. Based on these instruments, we can monitor chemical reactions and protein stability, determine molecular structures, obtain purity (including trace metal content), or study other properties of various materials.
The MicroCal PEAQ-DSC Automated system available in our facility provides high throughput, highly sensitive protein stability analysis with fully automated cell filling and cleaning functions for walk-away operations. DSC is most commonly used in biopharmaceutical development and manufacture for predicting and optimizing a product´s shelf life, the optimization of purification and manufacturing conditions, the assessment of biosimilarity and batch-to-batch comparability. In addition, the label-free stability data obtained by DSC can be applied for general stability studies, sensitive and reproducible analysis of protein folding and unfolding, characterization of lipids and detergent micelles etc.
Differential Scanning Calorimetry (DSC) is a powerful analytical technique for the characterization of the thermal stability of proteins and other biomolecules. These molecules often undergo thermally induced conformational changes, such as unfolding. When a protein unfolds, non-covalent bounds break and a new, probably non-functional structural arrangement is created. Differential scanning calorimeters measure the absorbed heat required for rearranging the conformational structure.
If you are interested in PEAQ-DSC Automated-based chemical and biomolecular analysis services, please do not hesitate to contact us.
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CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.