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Biological imaging is an important research tool for understanding tissue structure and elucidating the various physiological functions of living organisms. It uses light or electron microscopy to obtain direct images of the microstructure of biological cells and tissues, and the resulting images are analyzed to understand the various physiological processes of biological cells. CD BioSciences' Bioimaging Centre has dozens of devices and, more importantly, our expertise and experience are invaluable to the industries and clients we serve. We can provide Zeiss 880 at Wolf Hall-Confocal/Spectral/Airyscan-based bioimaging services.
Objectives: 5×/0.25, 10×/0.3, 20×/0.8, 40×/1.2 W, 40×/1.3 Oil, 63×/1.4 Oil.
Laser lines: 405 nm, 458 nm, 488 nm, 514 nm, 561 nm, 594 nm, 633 nm.
Detectors: a 32-channel ultra-sensitive spectral GaAsP PMT (Gallium Arsenide Phosphide PhotoMultiplier Tube) detector (i.e. ChS in Zen) which is ideal for spectral imaging, two multi-alkali PMT detectors (Ch1 & Ch2), one transmitted PMT (T-PMT) for contrast imaging (Bright Field, Differential Interference Contrast, Phase), and one GaAsP Airyscan detector for super-resolution and fast imaging.
Operating software: Zen 2.3 SP1
1. Confocal imaging.
2. Spectral imaging with linear unmixing. It can be used to remove background autofluorescence or for multicolor imaging when spectral overlaps between colors cannot be separated with standard confocal microscopy.
3. Super-resolution imaging. The Airyscan can provide a 2-fold increase in resolution compared to conventional confocal microscopy.
4. High-speed imaging. The Airyscan detector can be used to image 4 times faster than the confocal mode (up to 20fps at 512 × 512). The 880 is also equipped with a piezo-electric stage for high-speed acquisition of z-stacks.
5. Confocal reflection microscopy. It can be used to image collagen fibers and surface microtopography.
6. FRET, FRAP, FLIP.
7. Fluorescence Correlation Spectroscopy imaging. It provides quantitative data on concentrations, diffusion coefficients, molecular transport and interactions.
8. Tile scanning to image a large field at high resolution.
9. Live cell imaging thanks to the environmental enclo
The LSM 880 microscope is a fully automated multimodal microscope that can be used for confocal and spectral imaging. The Airyscan detector enables super-resolution and high speed imaging.
The LSM880 is fully equipped for live-cell imaging. It has an environmental enclosure (temperature, humidity, and CO2 control) and z-drift correction to maintain samples at the focal plane over time.
In recent years, with the development of optical imaging technology, especially the introduction of digital imaging and computer image analysis, bioimaging has become an indispensable method in cell biology research. CD BioSciences' bioimaging laboratory is committed to providing state-of-the-art technical support to our customers. If you are interested, please do not hesitate to contact us.
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CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.