Animal Imaging Service—Agilent Technologies/General Electric 7.0 Tesla Discovery MR901 System

CD BioSciences' animal imaging technology platform has multiple state-of-the-art instruments to study cardiovascular function, skeletal morphology, metabolism, and more by performing ultrasound and computed tomography imaging on live animals. Our Agilent Technologies/General Electric 7.0 Tesla Discovery MR901 System-based animal imaging service is the right choice for you.

Name of the Instrument/Platform

Agilent Technologies/General Electric 7.0 Tesla Discovery MR901 System

MANUFACTURER:

Agilent

Introduction

Equipment specifications
1. Sequences available
1) T1-, T2 and proton density-weighted Turbo-Spin Echo
2) 2D and 3D Gradient Echo
3) Spin Echo
4) Fluid attenuated inversion recovery (FLAIR)
5) Ultra-Short Echo Time Imaging (UTE) with TE of 80-100 microseconds
6) T1, T2 and T2* mapping sequences
7) Fast dynamic imaging (TRICKS)
8) Dixon/IDEAL fat fraction mapping
2. Radiofrequency probes /coils
1) ¹H / Proton:
a. 150 mm diameter quadrature send- and receive volume coil
b. 72 mm diameter quadrature send- and receive volume coil
c. 4-channel active decoupled receive rat brain coil
d. 2-channel active decoupled receive mouse brain coil
e. 2 cm diameter active decoupled loop coil for various dedicated applications
2) X-nuclei:
a. 2 cm diameter send and receive loop coils ranging from 26 MHz - 310 MHz (²H, ¹³C, ²³Na, ³¹P, ¹⁹F)

Feature Highlights

1. Perfect for anatomical imaging providing detailed 3D images of internal structures and revealing subtle abnormalities that cannot be identified with other imaging techniques (like radiographs or CT scans)
2. Non-invasive technique, does not use ionizing radiation to acquire images
3. Can be repeated and enables longitudinal studies
4. Excellent soft-tissue contrast (resolution ~100 µm)
5. For some diseases, MRI is the only imaging technique that can permit an accurate diagnosis
6. Capable of imaging live mice, rats, and other small animals (up to the size of a cat)
7. Can be used to quantitate imaging like e.g., fat-fraction mapping or tissue perfusion
8. Enables to depict tissue oedema or necrotic areas
9. Method of choice for imaging small lesions
10. Easy clinical translation

Applications

1. Optic nerve sizing
2. 3D Whole-body anatomical imaging
3. Vessel imaging
4. Cardiac (wall size, ventricular function)
5. Lung (to see tumors)
6. Kidney blood flow
7. Adipose tissue (whole-body imaging)
8. Stroke
9. Tumor (brain or body)
10. Spinal Cord
11. Bone metastases
12. Cerebral blood flow
13. Musculoskeletal
14. Phosphorus spectroscopy (work in progress)
15. Mouse head morphology
16. Fetal in-vivo
17. Ex-vivo sample imaging
18. Brain structure
19. Ultra-short-echo-time imaging (for imaging solids)

Summary

The MRI system is equipped with a 7.0 T, 310 mm diameter horizontal-bore superconducting magnet interfaced with General Electric 's Signa HDx platform. The system provides high quality and robust pre-clinical MRI research capabilities with a variety of imaging contrasts and quantitative assessments. PCIC provides a service to address a broad range of researchers' needs, from live animal imaging to specimen investigations and contrast agent characterization to material and plant research.
The imaging is performed using a strong 300 mT/m (30 Gauss/cm) gradient system (210 mm inner diameter) equipped with 2nd-order shim capability. A wide range of radio frequency probes (coils) are available, ranging from animal full body volume coils to dedicated, actively decoupled receive coils for mouse and rat brain. Systems for physiological monitoring and animal handling are also available. The MRI spectrometer is equipped with X-nuclei capabilities.

If you need to perform imaging studies on animals such as mice, please contact us directly for details.

For research use only, not intended for any clinical use.

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