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Optical microscopy, allows us to see and understand the microscopic world beyond our perception. Today, optical microscopy is at the heart of many scientific and technical fields, including life sciences, biology, materials science, nanotechnology, industrial inspection, medicine, and many more. CD BioSciences, the imaging experts, can provide you with optical microscopy imaging services based on Lattice Light-Sheet Microscope.
Microscope
We are typically using squared and hexagonal optical lattices in the dithered sample scan mode for high-speed volumetric imaging. Squared lattices are best-suited for almost no out-of-focus bleaching and lowest phototoxicity and can be used for single molecule imaging. The hexagonal lattices with its very thin central lob are providing the highest z-resolution with around 370 nm for green fluorescence at 500 nm. This lattices can also be used for structured illumination microscopy (SIM) to gain higher resolution in × and z-direction.
We established 3D-SIM as well as single molecule imaging in living cells. Currently, we are extending our SR repertoire by PALM, dSTORM and PAINT microscopy and non-linear SIM based on reversible patterned photoactivation. By adding adaptive optics, we want to increase resolution deeper inside cells, tissues and organisms.
Sample Preparation
Sample support needs to be an 100 µm thick coverslip with 5 mm in diameter (CS-5R, Warner Instruments).
This setup is a cutting-edge live cell imaging platform for multi-color high-speed volumetric imaging using thin light-sheets based on optical lattices.
CD BioSciences remains committed to providing you with a complete, state-of-the-art optical microscopy imaging service. If you are interested, please contact us directly.
Please fill out the form below and we will get back to you as soon as possible with a quotation for the item you are interested in.
CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.