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CD BioSciences' molecular imaging platform is equipped with state-of-the-art equipment and we are at the forefront of experimental animal imaging applications. We can provide a wide range of experimental animal models for image data acquisition and image data analysis. We can perform quantitative molecular imaging evaluation of animal models of various tumors, heart diseases, vascular diseases, neurodegenerative diseases, bone diseases, and other diseases.
1. Operation voltage: 300 kV
2. Electron source: X-FEG
3. Camera: Ceta 16M CMOS camera 300kV, Gatan K3 direct electron detector
4. Resolution limit: < 1.4 Å at 0 degree stage tilt; < 2.3 Å at 70 degree stage tilt.
5. Thon ring: < 3.5 Å at a defocus of -2 μm on a carbon film
6. Ice accumulation rate inside the column: < 0.7 nm/hr
7. Beam drift rate: < 0.3 μm per 24 hours
8. Beam intensity: <= 10% within 24 hours period of time
9. Stage Tilt Range: -70 to +70 degrees
10. Sample drift: < 0.5 nm/minute
11. Ice growth, contamination:
1) Samples in the column: up to 5 days with no observable contamination accumulation; Ice growth rate should be slow such that the transmission loss is less than 2% per 24 hours.
2) Samples stored in the sample exchange system: up to 3 days without observable contamination accumulation.
12. Position reproducibility of apertures: within 1.5 μm when the apertures are retracted and inserted
The Empire High-end EM at LBMS is a Thermo Scientific Krios G3i Cryo Transmission Electron Microscope (Cryo-TEM) that offers an easy, fast, and reliable way for life science imaging at the molecular and cellular levels. This instrument consists of a highly stable 300 kV TEM platform and a cryo-sample Autoloader designed for automated applications such as single particle analysis (SPA) and cryo-electron tomography (Cryo-ET). It has a K3 Direct Electron Detector with a BioQuantum energy filter for increased signal-to-noise ratio of recorded images.
CD BioSciences offers a highly regarded 'Empire' High-end Electron Microscope-based molecular imaging service. For more information, please do not hesitate to contact us.
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CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.