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Molecular Characterization Service—Isothermal Titration Calorimetry (Microcal iTC-200)

The characterization of molecules is an important part of the process, enabling the physical and chemical properties of molecules to be resolved. CD BioSciences has excellent analytical staff, years of analytical experience, and cutting-edge instrumentation. Using LC-MS, multiple HPLC, and other techniques, we can accurately quantify/characterize the DAR of coupled drugs, residual small molecules, endotoxins, and more.

Name of the Instrument/Platform

Isothermal Titration Calorimetry (Microcal iTC-200)

Introduction

This machine uses a far smaller sample volume than previous models (only 200 μL), opening this instrument to experiments with analytes that are difficult to produce in quantity. Please note that the design of this instrument was focused on biochemical/aqueous applications, so many organic solvents are incompatible with the iTC-200 (DMSO is acceptable).

Summary

The Microcal iTC-200 is designed to make very precise calculations of the binding energetics of analyte molecules, most commonly a protein and ligand. Through precise measurements of enthalpy changes produced by titration of one analyte into the other, this instrument can calculate binding constants and stoichiometry with a high degree of accuracy.

CD BioSciences offers its customers Isothermal Titration Calorimetry (Microcal iTC-200)-based molecular characterization services that contribute to the process and drug development process of biomolecules. If you need our technical support, please contact us directly.

For research use only, not intended for any clinical use.
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CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.

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