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Microscope Imaging Service—3i Lattice Light-sheet Microscope

As one of the leaders in the microscope imaging industry, CD BioSciences is widely recognized by our customers for reliable accuracy and continuous technological innovation. From light microscopy and digital microscopy, to ultra-high resolution, to electron microscopy sample preparation, we provide complete microscopy imaging solutions to customers in various fields such as life science research, manufacturing, and materials science.

Name of the Instrument/Platform

3i Lattice Light-sheet Microscope

Introduction

Specifications:
1. Sample must be mounted on 5 mm coverslips
2. Only staff-assisted usage (not for self-use)

Applications

1. High-speed, high-resolution 3D imaging (< 0.3s/z-stack)
2. Deep 4-color 3D-imaging
3. Minimal phototoxicity

Summary

Invented by Nobel-laureate Eric Betzig, this microscope is uniquely suited for high-resolution 3D imaging by reducing light-induced damage to an astounding minimum. Unlike traditional microscopes that irradiate nearly the whole sample just to capture a thin slice of information, the LLSM uses a lattice-pattern of unique pencil-like beams, thus limiting the volume of irradiation to the slice being imaged (Chen et al 2014 Science 346, 1257998). From an innovative combination of new tools in physics, the beams are thinner and longer than any other microscope. The strategy is so efficient that continuous fluorescence movies of developing organisms have no detectable phototoxic effect, even on their offspring. Furthermore, the spacing of the lattice-pattern is adjustable and can be exploited to provide super-resolution images, trading speed for improved resolution in all dimensions, thus exceeding confocal microscopy. Indeed, Dr. Betzig claims that the LLSM is better than the microscope tec

CD BioSciences offers 3i Lattice Light-sheet Microscope-based microscopy imaging solutions that are a powerful support for your research. If you are interested in our services, please feel free to contact us.

For research use only, not intended for any clinical use.
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