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High-throughput screening technology is designed to screen a large number of biomodulators against selected targets and is applied to screen different types of libraries such as chemical, genomics, protein, and peptide libraries. CD BioSciences, the industry leader in high-throughput screening services, provides high-quality, customized high-throughput screening services. Services cover both biochemical and cell-based assays.
Tycho verifies protein quality by looking at the structural integrity (or foldedness) of a protein. As a thermal ramp is applied, the changes in the intrinsic fluorescence, detected at both 350 nm and 330 nm, from tryptophan and tyrosine residues in the protein are measured. These changes in fluorescence signal indicate transitions in the folding state of a protein. The temperature at which a transition occurs is called the inflection temperature (Ti). The fluorescence is recorded during the thermal run, plotted as ratio and used to calculate Ti. Its initial value along with the change in signal over the run (Δ ratio) is also recorded.
CD BioSciences' Nanotemper NT.6-based high-throughput screening solutions are available to meet a wide range of high-throughput experimental needs. We have standard workflows, application expertise, customized designs, comprehensive after-sales service, and extensive technical support resources. If you are interested, please contact us directly.
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