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Combining CD BioSciences' strong protein production capabilities with powerful biophysical and biochemical analytical techniques and accumulated experience in the direction of crystal structures, our Crystal Structures Division can provide quality crystallization services to meet the needs of our customers.
METHODS & EXPERTISE FOR RESEARCH INFRASTRUCTURE
The crystallisation of a biomolecule represents a major challenge in the determination of its three-dimensional structure. The crystallisation robot enables the miniaturization of crystallisation campaigns to the nanolitre scale. This reduction enables an up to 100-fold reduction of the required protein, or conversely, a corresponding depth increase of the crystallization campaigns with identical protein usage. Importantly, this nanoliter robotics allow to carry out structural investigations on proteins, which can be produced at inherently low yield, e.g., membrane proteins. Finally, by its unique contamination-free working procedure the robot also qualifies for sensitive pipetting applications such as (epi) genomics.
Crystallisation campaigns
The device consists of: 8-channel pipetting unit; Coil with 26,000 pipettes; Pipette loading unit; Calibration block; Guide block; Welding bracket for hanging drop applications; Computer; Control and evaluation software. The device allows reproducible pipetting steps in the volume range 25 nl to 1.2 µL with highly viscous liquids, a humidity chamber provides protection against evaporation of the nanoliter drops.
CD BioSciences offers Kristallisationsroboter Mosquito Xtal3-based crystallization services. If you are interested, please contact us directly.
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CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.