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CD BioSciences combines experimental data with theoretical analysis methods to provide a AVANCE III HD 600 MHz Spektrometer-based crystal structure determination service for the confirmation of 3D structure information of pharmaceutical crystals.
METHODS & EXPERTISE FOR RESEARCH INFRASTRUCTURE
The device is used for the investigation of biological systems such as proteins, peptides and oligosaccharides. The applications range from the structural confirmation of peptides (chemical structure) to the three-dimensional structure determination of proteins.
A focus is the mapping of protein interaction sites with binding partners to the protein sequence as well as the localization of the binding on the ligand side.
Another focus is on the detection of post-translational modifications.
Smaller tasks are the chemical structure elucidation of small molecules, e.g. purified unknown substances, or the confirmation of the identity of substances which were acquired either commercially or from co-operation partners.
Furthermore, the chemically working groups at the University of Salzburg (for example, Prof. Nicola Hüsing, Department of Chemistry and Physics of Materials) are supported by routine measurements (one-dimensional 1H a
Preliminary experiments for biomolecules (e.g., "fingerprint" 1H-15N two-dimensional protein spectrum) to determine whether a protein is suitable for NMR binding studies and / or three-dimensional NMR structure determination.
Nuclear resonance spectrometer for applications of chemical structure elucidation, including small molecules and modern biological applications such as protein structure elucidation, protein interactions, of the analysis of post-translational modifications. The system consists of a superconducting magnet (14 Tesla), 1H/13C/15N/31P quadrupole probe head, sample changer for 24 samples, console (frequency generation, amplifier, lock, gradient unit), Temperature unit (-15 to 60℃), Linux Workstation, Ultra stabilized power supply (UPS for 11 min). The system can automatically measure sequentially up to 24 samples (typical for the elucidation of the chemical structure of small molecules) or highly complex experiments for the protein signal assignment and protein structure elucidation, extending over several days or weeks.
CD BioSciences' AVANCE III HD 600 MHz Spektrometer-based technical support enables highly accurate crystal structure determination within 2-3 days. If you are interested, please contact us directly.
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CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.