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The CD BioSciences biophysical characterisation laboratories are equipped with state-of-the-art instruments for studying proteins, nucleic acids, lipids, and complexes. Researchers can benefit from our Wyatt Technology/Agilent SEC-MALS-based biophysical characterisation services.
Conventional size exclusion chromatography relies on reference standards that do not accurately represent your molecules. SEC-MALS measures molar mass directly, independent of elution time, for confidence in reported values.
Not all macromolecules behave alike. Your samples may have a different conformation than molecular standards or exhibit unexpected column interactions. As an absolute technique for determining molar mass and rms radius rg in solution, SEC-MALS - the combination of Size Exclusion Chromatography with Multi-Angle Light Scattering analysis - overcomes the limitations of column calibration.
SEC- MALS-coupled with an analytical HPLC system can be used characterize:
• Heterogeneous biopolymers and synthetic polymers
• Oligomers and aggregates
• Conjugates such as ADCs, PEGylated proteins, or block co-polymers
• Multi-angle static light scattering (MALS) requires precise alignment of the beam direction, laser polarization and detector position in order to provide accurate measurements.
Users will need to provide their own columns and mobile phases.
Size Exclusion Chromatography-Multi-Angle Light Scattering (SEC-MALS) measures molar mass directly, independent of elution time. As an absolute technique, SEC-MALS is used to characterize such attributes as the aggregation state of proteins and the stoichiometry of complexes.
In the chemistry-biology community, our service is one of the best options for teams working on biophysical characterisation. Do not hesitate to contact us if you are interested in this.
Please fill out the form below and we will get back to you as soon as possible with a quotation for the item you are interested in.
CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.