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The CD BioSciences biophysical characterisation laboratories are equipped with state-of-the-art instruments for studying proteins, nucleic acids, lipids, and complexes. Researchers can benefit from our Jasco 815 Circular Dichroism (CD) Spectrometer-based biophysical characterisation services.
1. Characterization of protein secondary and tertiary structure
2. Studying the conformational stability of a protein at varying temperature, pH or denaturant concentrations
3. Determination of the effects of protein-protein interactions on conformation
4. Comparing the structures of protein vs. mutants or proteins expressed in different systems
Circular dichroism measures the interaction of circularly polarized light with molecules. Circularly polarized light interacts equally with non-chiral molecules so non-chiral molecules are not measured. As the circularly polarized light passes through an optically active substance, its two circularly polarized components travel at different speeds and are absorbed in differing degrees. The Jasco 815 CD spectrometer can measure conformation in chiral molecules. CD spectra between 260 and approximately 190 nm can be analyzed for secondary structural elements: alpha helix, parallel and anti-parallel beta sheet, turn, and other. The absence of regular structure results in zero CD intensity, while an ordered structure reveals a spectrum that can contain both positive and negative signals.
In the chemistry-biology community, our service is one of the best options for teams working on biophysical characterisation. Do not hesitate to contact us if you are interested in this.
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CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.