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Bioimaging Service—Transmission Electron Microscope JEOL 1400 TEM

Transmission electron microscopy is an important tool for the observation and study of ultrastructure and is widely used in a variety of disciplines such as histology, cytology, virology, pathology, and materials science, for example, to observe the overall structure of cells, changes in cell membranes, organelles in cell walls, the distribution of materials into cells, autophagic vesicles produced by cells in response to external stimuli, and invasive structures invaded by external organisms. CD BioSciences' JEOL 1400 TEM-based bioimaging service enables customers to see the microscopic world.

Name of the Instrument/Platform

Transmission Electron Microscope JEOL 1400 TEM

Feature Highlights

Accelerating voltage: 80-200kV
Filament: LaB6
Camera: Gatan OneView detector
Resolution: 0.14 nm
Magnification: x30 to x8,000,000
Extra features: Scanning Transmission Electron Microscope (STEM) mode for tomography of thick resin sections
Intended use: Higher end TEM for more advanced imaging (eg: tomography, negative stain Single Particle Analysis)

Applications

Screening negatively stained particulate samples (eg: viruses, bacteria, protein and liposomes)
Characterisation of cellular ultrastructure (eg: mitochondria, centrosomes etc)
Subcellular localisation of proteins using immunogold labelling
Correlative light and electron microscopy (CLEM) to place fluorescent proteins/markers in ultrastructural context
Electron tomography for high resolution 3D reconstructions of organelles and particulate samples, including using STEM.

Summary

These microscopes are more user friendly and higher resolution than our old T12 TEM. They are equipped with high resolution, ultra-fast CMOS cameras to help you get the best ultrastructural images possible. In particular, the JEOL 2100Plus dramatically expands our 3D imaging capabilities at the organelle and cellular levels. This microscope enables higher resolution EM tomography, as well as STEM tomography, to be performed on thicker resin sections and also introduces TEM array tomography capability to our facility, which is very exciting!

CD BioSciences offers you JEOL 1400 TEM-based bioimaging services to help you solve your research problems related to proteomics, metabolomics, lipidomics, and more. If you are interested, please contact us directly.

For research use only, not intended for any clinical use.
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CD BioSciences is committed to providing a tailored service to researchers working in the fields of biology and chemistry. Our mission is to accelerate the progress of your research through our technical support.

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