Animal Imaging Service—Mediso NanoPET-CT Small Animal Imaging System

CD BioSciences' animal imaging technology platform has multiple state-of-the-art instruments to study cardiovascular function, skeletal morphology, metabolism, and more by performing ultrasound and computed tomography imaging on live animals. Our Mediso NanoPET-CT Small Animal Imaging System-based animal imaging service is the right choice for you.

Name of the Instrument/Platform

Mediso NanoPET-CT Small Animal Imaging System

Introduction

• PET-CT technical specifications
1. 16 cm gantry bore to accommodate imaging of mice, rats and rabbits with interchangeable beds and radiation shields
2. Low dose CT protocols (< 50mGy for a three minute scan) are compatible with longitudinal rodent studies
3. Imaging beds provide integrated animal support, with gas anaesthesia and controlled heating and monitoring
4. Open access system with a one-step animal loading procedure and single motion PET and CT acquisition to enable automatic fusion of PET and CT images
5. Reconstructed PET resolution is 1 mm and CT resolution is down to 10 micron
6. Axial scanning up to 300 mm and transaxial scanning up to 125 mm
7. ARA-MBI PET-CT
• Compatible equipment
1. Up to four mice can be imaged simultaneously with the four-animal bed
2. VivoQuant software for analysis is available in the PET/CT room
3. Isoflurane anaesthesia and necessary physiological monitoring (temperature, respiration, heart rate)
4. On-site radio-HPLC for radiometabolite and k

Feature Highlights

1. High sensitivity and resolution; increasing signal to noise, reducing radiation exposure and scan times - ultimately reducing study numbers and enabling multiple scans in the same animal
2. Multi-bed increases throughput and ensures efficient use of radioligands
3. Combined PET/CT enables precision anatomical localisation of radiotracer without requirement for MRI (dependent on application)
4. Physiologically gated acquisitions for optimal in-vivo lung imaging

Applications

1. Wide range of molecular imaging and computed tomography applications for studies of animal models of health and disease, drug discovery and toxicology
2. Bench to bedside and back again translational applications
3. Receptor/enzyme/transporter mapping, evaluation of metabolism, glucose metabolism, drug receptor occupancy/kinetics, molecular/anatomical biomarkers for disease aetiology, ontology, prognosis, therapeutic efficacy, patient segregation etc
4. High-resolution anatomical assessment of both soft and hard tissue in vivo, post-mortem, surgical resections/biopsies

Technical Capabilities

1. Can be flexibly configured to acquire PET/CT, PET or CT
2. > 1 mm FWHM PET resolution
3. > 10 µm CT resolution
4. Optimised for low dose radiotracer/X-ray acquisitions enabling longitudinal in-vivo studies
5. Whole animal PET/CT (300 mm × 125 × 125 mm)

Summary

The Mediso NanoPET/CT is a small animal preclinical scanner suitable for a wide variety of radioactive tracer imaging and computer tomography (CT). Typical applications for PET tracers include oncology, cardiology, metabolic, neurodegeneration and obesity research. The CT component is ideally suited to a number of applications including bone, organ, anatomy and developmental biology research.

If you need to perform imaging studies on animals such as mice, please contact us directly for details.

For research use only, not intended for any clinical use.

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